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ETHICS APPROVAL AND CONSENT TO PARTICIPATE All animal experiments were conducted in strict accordance with the Guidelines for the Care and Use of Laboratory Animals of Naval Medical University, China, and approved by the Animal Ethics Committee of Naval Medical University

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In one randomized controlled trial, significant improvements compared with placebo were observed on the MADRS and Bipolar Depression Rating Scale (BDRS) and on secondary outcome measures of clinical status, quality of life, and functioning [142]